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KMID : 1149220030110010161
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Korean Journal of Oriental Medical Prescription
2003 Volume.11 No. 1 p.161 ~ p.170
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Effects of Jakyakgamchotang extract on the Analgesic effect in Mice
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Lee Gi-Ok
Kook Yoon-Bum
Yun Young-Gab
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Abstract
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This study was designed to elucidate the analgesic effects of Jakyakgamchotang and Radix paeinia, Radix Glycyrrhiziae which are the component of Jakyakgamchotang in mice. The analgesic effects were measured by the Whittle’s method and hot plate method. The results were as follows ; After the administration of Jakyakgamchotang extrace, the frequency of writhing syndrome was significantly inhibited. After the administration of Radix paeinia extract, the frequency of writhing syndrome was significantly inhibited. After the administration of Radix Glycyrrhiziae extract, the frequency of writhing syndrome was significantly inhibited. After the administration of Jakyakgamchotang extrace, paw licking time and escape time were significantly prolonged. After the administration of Radix paeinia extract, paw licking time was significantly prolonged. After the administration of Radix Glycyrrhiziae extract, paw licking time was significantly prolonged. It is concluded that the analgesic effects of Jakyakgamchotang were found to be more effective than Radix paeinia and Radix Glycyrrhiziae.
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KEYWORD
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Jakyakgamchotang, writhing syndrome, Analgesic action, paw licking time
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